Received August 29, 2020
Accepted February 15, 2021

Objective: The purpose of this study was to investigate the possible impact of follicular flushing on the amount of oocytes recovered and oocytes in metaphase II in patients with low ovarian response (POR), when compared to direct aspiration. Methods: Prospective, comparative, randomized single center study, with 208 punctures of patients with POR, submitted to assisted reproduction technologies (ART). Two groups were compared, one using a double lumen needle (Wallace DNS1733) for follicular flushing (n:105) and another single lumen needle (Wallace ONS1733) for direct aspiration (n:103), when ≤5 follicles between 15-17mm, ≤4 follicles above 18 mm on hCG day and ≤7 recovered oocytes. Results: There were no differences in age 39.07±3.88 x 38.11±3.43, weight 61.73±17.53 x 65.96±15.44, AMH 0.63±0.59 x 0.94±0.97, stimulation days 9.57±1.87 x 10.29±2.82, estradiol levels 788.94±670.82 x 940.16±694.69, progesterone 617.29±319.76 x 561.18±486.78 and follicles ≥18mm 1.84±0.95 x 2.07±1.09. Although the total of gonadotropins 1678.28±798.52 x 2080.45±852.36 (p=0.0008), number of aspirated oocytes 3.00 ± 2.11 x 3.69±2.20 (p=0.02) and metaphase II 2.20±1.64 x 2.99±1.88 (p=0.02) were significantly different, the oocyte / follicle ratio ≥15mm (0.93 x 0.98) and oocytes in metaphase II/follicles ≥15mm (0.68 x 0.79) were similar in both groups. The failure to capture was 16%x9.8%. Conclusion: Considering that there was no difference in the oocyte per follicle ratio, follicular flushing did not increase the number of oocytes recovered from poor responders.