Received October 10, 2020
Accepted April 22, 2021

Objective: To study donor and recipient factors affecting cumulative live birth rate (CLBR) in oocyte donor IVF (OD-IVF) cycles. Methods:The present retrospective study was conducted at ART centre of a tertiary care referral hospital after ethical approval and included all OD-IVF cycles done between January 2014-October 2019. Donor parameters included age, body mass index (BMI), ovarian reserve markers, serum estradiol (E2) on day of trigger and number of total/grade 1 oocytes; recipient parameters included age and BMI. Primary outcome was CLBR resulting from one complete donor-recipient (D-R) cycle through fresh/frozen embryo transfer. Secondary outcomes included number of total and grade 1 oocytes, fertilization and cleavage rate and clinical pregnancy rate (CPR). Results: Total 262 D-R cycles were analysed for donor characteristics and 260 cycle were analysed for CLBR. Mean age of recipients was 35.20 ± 4.05 and of donors was 25.29 ± 2.03 years. The CPR and CLBR per started cycle was 60% and 55.7% respectively. BMI of recipient and grade 1 oocytes were found to be independent predictors of CLBR in multivariate analysis. As the number of grade 1 oocytes increased, chances of live birth increased by 10% (95% CI, 1.04 – 1.32, P=0.008). Recipient BMI ≥25 kg/m² reduced chances of CLBR by 50% (95% CI, 0.27 -0.81, P =0.007). Conclusion: Number of grade 1 oocytes and recipient BMI significantly affect CLBR in OD-IVF cycles. Recipients with BMI ≥25 kg/m² may be advised weight reduction strategies to improve CLBR.