Received December 19, 2020
Accepted April 15, 2021

The platelet-rich plasma (PRP) methodology has been used in several areas of medicine due to its ability to promote tissue regeneration by growth factors and cytokines. This review addresses the use of PRP to rejuvenate ovarian follicles and increase the thickness of the endometrium for receiving the embryo. PRP is obtained from the patient's own blood (autologous blood) - a fact that determines a lower chance of rejection reactions. Alpha granules of platelets provide and release supra physiological amounts of growth factors and cytokines, which provide a regenerative stimulus in tissues with low healing potential. In the ovary, the PRP, with its growth factors, stimulates vascularization and recruitment of primordial follicles that still exist, but that could no longer be stimulated. The rejuvenation of the ovary by PRP infusion aims to obtain new oocytes in ovaries with low numbers of follicles, or with low follicular reserve markers. In the preparation of the endometrium, the PRP technique is used due to the action of its several different growth factors that would allow tissue proliferation and endometrial thickening, especially in cases of endometrium that are difficult to prepare, or that do not reach an adequate minimum thickness (>7mm). To date, there are few studies of greater expression in the literature that support the use of PRP in both proposed actions. Thus, although promising, the technique must still be validated by larger clinical trials.