Received December 15, 2020
Accepted June 30, 2021

Objective: Data on the possible influence of women´s region of residence, within the same country, on the outcomes of medically assisted reproduction cycles are scarce. This study aims to assess the impact of the women's region of residence on the results of in-vitro fertilization cycles. Materials and Methods: In-vitro fertilization cycles between 2010 and 2017 performed in a northern Portugal assisted reproduction center were evaluated. Two groups were defined: Douro Litoral (group 1; n=783), and Trás-os-Montes and Alto Douro (group 2; n=178). Demographic and cycle-related variables were analyzed, and rates were calculated for cycles with embryo transfer. Mann -Whitney and Chi-square tests were used. P<0.05 was considered statistical significant. Results: A total of 961 cycles were included. The region of residence had no effect on the variables women´s age, body mass index, or duration of infertility (P>0,05). Group 2 had a statistical significant lower number of previous cycles than group 1 (1,3±0,5 and 1,5±0,7; P=0,005). In the sub-analysis of cycles with embryo transfer (n=781), group 1 obtained higher rates of normal fertilization (62,5% vs 57,5%; P=0,04), miscarriage rate (30,0 vs 10,9%; P=0,007), and lower implantation rate compared to group 2 (33,3% vs 50,0%; P<0,001). Conclusion: Women from the region of Trás-os-Montes e Alto Douro had a lower number of previous cycles, compared to those from the Douro Litoral, despite the absence of statistical significant differences in terms of age or infertility´s duration. These findings reinforce the need to contemplate the sociodemographic and socioeconomic variables in this context.