Received December 23, 2020
Accepted June 30, 2021

Objective Repeated implantation failure (RIF) is a major challenge in reproductive medicine. On the other hand, there has not yet been established a confirmed result regarding the usage of platelet-rich plasma (PRP) in women undergoing intracytoplasmic injection (ICSI) or in-vitro fertilization (IVF); hence, the objective of this study was to evaluate the effect of the intrauterine infusion of PRP on the pregnancy outcomes in women undergoing ICSI. Material &Method In this prospective double-blind clinical trial, 100 women with at least two previous unexplained RIF, who were candidates for frozen-thawed embryo transfer, were allocated into two groups. One subgroup of patients was treated by intrauterine infusion of PRP (0.5CC, contained platelet 4-5 times more than a peripheral blood sample, which was performed 48 hours before blastocyst transfer) and the other subgroup were treated by only intrauterine catheterization. The implantation rates were compared between the two groups. Results in the intervention subgroup pregnancy rate weres 20%, while in the control subgroup it was 13.33%, and therefore, there was a significant statistical difference between the two groups. Conclusion According to this paper, it is possible that PRP could be successful in improving the pregnancy outcome in RIF patients while it is highly recommended that other studies with a larger sample size evaluate the efficacy of PRP therapy in RIF patients.