Received February 22, 2021
Accepted August 31, 2021

Carbon nanostructures are important nanomaterial with interesting physical and chemical properties. These nanostructures have been assessed for application in different fields of medicine such as cancer treatment and detection, Parkinson disease, reproductive medicine, and etc. These nanomaterial can be used in reproductive medicine as drug delivery system, antifungal, antiviral, and antibacterial agents, condom-coating agents, enhancer of sperm fertilizing ability, treatment of ectopic pregnancy, trophoblastic diseases, endometriosis, and uterine fibroids, and Assisted Reproduction Techniques (ART) improvement. Other side of this coin is various side effects of carbon nanostructures, especially negative effects on reproductive systems. All carbon nanostructures Showed toxicity on reproductive system by production of reactive oxygen species and oxidative stress. Due to the unique properties of carbon nanostructures as well as their practical attractiveness, other side of this coin, namely the risks and side effects of these compounds, especially in the case of reproductive system that depends on the survival and health of future generations, has taken less attention. So, we suggest paying particular attention to the negative aspects of the increasing use of carbon nanostructures.