Received February 02, 2021
Accepted August 29, 2021

The impact of the gonadotropins used for COS on the rate of embryo aneuploidy in patients without the negative effect of age acting as a confounding factor is still a subject of lively debate. A systematic search for studies was performed at MEDLINE, PubMed, Google Scholar, and Cochrane Library. Searches were coordinated by a librarian in December’19. All original English, peer-reviewed articles, irrespective of study-design, were included. There were no restrictions in the amplification method, or the platform used to analyze the amplified DNA. The PICO model was used to select the study population. Women/couples who underwent COS for an IVF with the intention to genetically analyze her/their embryos through PGT were included. The primary outcome was aneuploidy rate. The Newcastle–Ottawa scale (NOS) score was used to evaluate the quality of the studies included. The search retrieved 73 citations and 14 were eligible for analysis, which included data on 4805 cycles. Media quality NOS score was 8. Although it has been demonstrated that natural cycles are associated with aneuploidy, it does seem that more robust stimulations are indeed associated with a higher proportion of aneuploidy. Nevertheless, a higher response is associated with an increased total number of euploid embryos available for transfer, which translates into more embryo-transfer cycles with a prospective higher cumulative live birth rate. Further evidence is needed to ascertain if there is a negative impact of COS, especially at the cellular level.