Received April 09, 2021
Accepted October 10, 2021

Objective: To understand which of the controlled ovarian stimulation (COS) protocols, used in different patients are related to a greater amount of oocytes recovered. Methods: The sample was divided into three groups, considering the, AMH and the AFC to obtain the Ovarian Response Predictor Index (ORPI) and consequent grouping into: G1-Low Reserve (ORPI <0.5), G2-Normal Reserve (ORPI:0.5-0.9) and G3-High Reserve (ORPI≥0.9). 246 cycles were selected in which COS was used: recombinant FSH - follitropin alfa or beta (Protocol 1) or corifollitropin alfa (Protocol 2), both associated with urinary HMG and the GnRH antagonist, with the trigger performed using recombinant hCG or GnRH agonist. Results: The number of oocytes obtained was higher in protocol 1 in all groups studied, being more significant in G1 than in G2 and G3. The number of days required in COS for protocol 2 was greater than for protocol 1 in all groups. The total dose of recombinant FSH alfa or beta / urinary HMG used in protocol 1 was inversely proportional to the ovarian reserve. The lower the ORPI, the greater the average number of international units administered. In protocol 2 there was a need to supplement with higher doses of urinary HMG when compared to protocol 1. The dosage of the GnRH antagonist was dependent on the number of COS days until the trigger was used. In obtaining MII oocytes, the percentages were similar regardless of the trigger used. Conclusion: The use of follitropin leads to the obtaining of a greater amount of recovered oocytes than corifollitropin alfa in all ORPIs. The dose of recombinant FSH used with urinary HMG increases inversely proportional to the ORPI value. The fixed dose of recombinant FSH deposit requires a sharp increase in the dose of urinary HMG.