Received January 31, 2021
Accepted July 31, 2021

Objective:to compare the number of oocytes obtained in the follicular puncture of high responder oocyte donors submitted to ovarian stimulation for in vitro fertilization(IVF)in two different protocols: friendly and conventional. Methods:One hundred and eight infertile egg donor women aged between21and35years undergoing in IVF in this retrospective cohort study.The women were divided into two groups:1)Friendly protocol:controlled ovarian stimulation(COS)with corifollitropin alpha,clomiphene citrate and dydrogesterone without daily rFSH(n = 52)and2)Conventional Protocol: COS with menotropin daily and ganirelix(n = 66).Age, body mass index,time and cause of infertility,antral follicle count(AFC)by three-dimensional ultrasound,number of visits to the clinic,duration of COS,number of follicles≥14mm on the trigger day,early ovulation frequency,number of mature oocytes,number of cryopreserved embryos,clinical pregnancy rate,frequency of OHSS were evaluated. Results:The ovulatory factor was higher in women in the conventional protocol(p = 0.03)and the tubal factor(p = 0.02)was higher in the friendly protocol group.The number of visits to the clinic was lower among women from the friendly protocol(p = 0.04).The number of mature eggs,the clinical pregnancy rate and the frequency of OHSS were similar between groups.The number of frozen embryos was higher in the friendly group(p = 0.02).The regression model demonstrated that the ovulatory factor,the tubal factor and the number of visits to the clinic were not predictors of the number of mature oocytes.Only AFC was an independent predictor of the number of meiosis II oocytes(p <0.01). Conclusion:The use of the friendly protocol seems to be as safe and effective(the same number of oocytes and OHSS risk)as conventional protocol for infertile high responder oocyte donors.