German David Ospina Idárraga, Iván Darío Montes Suárez, Katherine Hernández Osorio, Diana Milena Diaz Corredor, Johanna Carolina Paéz Redondo, Ricardo Garcia Yepes
JBRA Assist. Reprod. 2022; 26 (2):280-287
Received October 03, 2021
Accepted August 15, 2021
Abstract
Objective: To analyze the results of the preimplantation genetic testing for aneuploidy at the Human Fertility Institute InSer in Bogotá, Colombia, from 2016 to 2020.
Materials and Methods: This research is an observational, retrospective, and correlative analysis of biopsies from 319 embryos (from 54 patients) submitted to preimplantation genetic testing for aneuploidy by different molecular techniques.
Results: Of the 54 patients included in the study, 42 provided their own oocytes, and 12 used donated oocytes. The main indication to perform the preimplantation genetic testing was advanced maternal age. A total of 319 embryos were obtained: Ninety-one (28.5 %) euploid, 197 (61.8 %) aneuploid and 31 (9.7%) with no detectable DNA. The highest rate of aneuploid embryos was found in patients over 40 years (72.7 %), and the euploidy rate in patients under 35 years was 37.1 %. After the transfer of euploid embryos, the rates for implantation, ongoing pregnancy, live birth, and miscarriage were 40 %, 50 %, 40.6 %, and 0 %, respectively. Older maternal age correlated with higher numbers of aneuploid embryos and lower numbers of both euploid and 5-day embryos.
Conclusions: A positive correlation was found between maternal age and aneuploidy rate. Complex chromosomal abnormalities were the most frequent aneuploidy followed by mosaicism and double aneuploidies. The miscarriage rate after the transfer of euploid embryos was 0 %.