Received July 28, 2021
Accepted January 30, 2022

Introduction: the Brazilian Federal Council of Medicine (CFM) resolution number 2294/21, which regulates the use of procedures in human reproduction in Brazil, brought significant and important changes to clinical practice in assisted human reproduction, which raise ethical, bioethical, and legal discussions between professionals and patients. Objective: this study aims to analyze these changes in these different aspects, especially because some aspects are controversial in the CFM resolution number 2294/21 Methods: evidence-based knowledge resources were used to support the analysis of crucial points that were modified by this change. A literature review was carried out to obtain information about guidelines and laws, as well as articles that contemplate ethical discussions about assisted reproduction. The search sites used were BVS, Pub Med, LILACS and Google Scholar. The keywords used were law, legislation, bioethics, reference guide and assisted human reproduction. Relevant official documents from the Brazilian State were also identified and included in the survey. Conclusions: the new resolution regarding the use of assisted reproduction techniques brought important changes, with clinical implications for couples who wish to become pregnant, and there is a need for a broad discussion of these repercussions from a clinical, ethical, bioethical, and legal point of view.