Received September 10, 2021
Accepted March 29, 2022

Objective: In this study, the influence of Alpinia officinarum rhizome extract (AO) on the alleviation of testicular damage induced by cisplatin in rats was evaluated. Methods: Study groups include the control group, AO-administered group, cisplatin-administered group, and three groups administered with cisplatin and AO (different concentrations of 100, 200, and 400 mg/kg). On the 14th day, the testes of the rats were removed and testicular organ parameters were measured. Moreover, through evaluating malondialdehyde concentration, oxidative stress was evaluated and superoxide dismutase (SOD) activity of testes and histopathological analysis were also carried out. Results: The results demonstrated that cisplatin-induced oxidative stress and severe testicular damage and the AO-administered group showed no harm compared with the control group. AO treatment in cisplatin-received rats led to the reduction of oxidative stress, enhancement of SOD activity, and prevention of testicular damage. The lowest testis damage was attributed to the group received 400 mg/kg AO compared to 100 and 200 mg/kg. Conclusion: Overall, the Cis+/AO+400 group exhibited the best antioxidant properties. The findings could lead to changes in cancer care guidelines that incorporate phytochemicals, making cancer therapies safer.