Received August 08, 2021
Accepted February 27, 2022

Background: This study assesses some potential risk factors in assisted reproductive technology pregnancies Patients and methods: a retrospective cohort of 195 pregnancies, defined as serum human chorionic gonadotrophins ≥ 10 IU/l on day 14 – 17 after embryo transfer, were recruited in this study from assisted reproductive technology unit, Ain Shams & Al-Azhar Maternity hospital, cairo, Egypt, during the period from January 1st, 2016 to December 31, 2020. Risk factors investigated were maternal age, body mass index, status, basal hormonal profiles, treatment protocol and quality and number of embryos. Results: overall early pregnancy loss among the studied 195 pregnant women was 29 cases (15%). The risk of early pregnancy loss was associated with older age and number of emryos transferred. Women > 35 years were found to have two and half times of early pregnancy loss compared with younger age group < 25 years, this was not significant after adjusting for other factors. The risk in both lean (BMI < 25 kg/m2) and very obese (BMI > 35 kg/m2) women was also not significantly higher in unadjusted analysis. Transfer of two or more embryos was associated with a non significant reduced risk of early pregnancy loss, and after adjusting for other factors, the reduction was about 70%. Conclusion: Obesity and other factors appeared to have a minor role. More studies are needed to confirm or refute these findings.