Received September 13, 2021
Accepted December 21, 2021

Objectives:A successful ART (assisted reproductive techniques) cycle is not flawless and several studies have reported high incidences of maternal complications, but the association is inconclusive. Also, the effect of racially and ethnic distinguished Asian population undergoing ART on maternal outcomes is not well studied. This study attempts to compare various maternal outcome parameters ART and spontaneously conceived singleton pregnancies from a single high volume tertiary care centre. Methods:A retrospective cohort study from a single tertiary infertility centre was conducted from January 2011 to September 2020. The study included 1125 IVF conceived singletons (AP group) and 7193 spontaneous conceived singletons (SP group). The groups were compared using the Pearson Chi-square test and the adjusted odds ratio calculated using multivariate analysis. Results:Maternal outcomes like gestational hypertension, pre-eclampsia, gestational diabetes (GDM), oligohydramnios, chorioamnionitis, operative, and instrumental delivery were significantly different in the two groups (p <0.05). AP group had a significantly increased risk of GDM (aOR 1.093; 95% CI 1.076-1.110) and pregnancy induced hypertension (PIH) (aOR 1.577; 95% CI 1.288-1.930) as compared to the SP group. The IVF significantly increases the risk of abruption by 2 times (p=0.028) and independently increases the risk of caesarean section by 3.1 fold (p<0.001). But overall the IVF is the protective factor for oligohydramnios (p=0.024). Conclusions: ART increases the likelihood of pregnancy-related maternal complications like PIH, GDM, abruption, chorioamnionitis, and increased rate of caesarean delivery. Thus, all patients undergoing ART procedures should receive pre-conceptional counselling regarding the associated obstetric risks and consider ART pregnancy as a high-risk pregnancy.