Received February 14, 2022
Accepted September 26, 2022

Objective: To evaluate clinical and laboratory outcomes of oocyte donation cycles and compare the results from donors and recipients. Methods: A retrospective cohort study was conducted at a reproductive medicine center. A 586 first fresh oocyte donation cycles, performed from 01/2002 to 12/2017 were included. The outcomes of 290 cycles from donors and 296 from recipients, resulting in 473 fresh embryo transfers, were analyzed. The oocyte division was equally made, whereas, at an odd amount, the donor always had a preference. The data were collected from an electronic database, and analysed using Chi-square test, Fisher's exact test, Mann–Whitney U-test or Student t-test depending on the data distribution, and multivariate logistic regression, considering p<0.05. Results: Both groups presented good fertilization rates (72.0±21.4 vs. 74.6±24.2, p<0.001). Implantation rate (46.2% vs. 48.5%, p=0.67); clinical pregnancy (41.9% vs. 37.7%, p=0.39), and live birth rates by transfer (33.3 vs.37.7, p=0.54) were similar between groups. Conclusion: Oocyte donation is often the way donors can access in vitro fertilization, and for recipients seems to be a good option for pregnancy. Demographic and clinical characteristics have a secondary role in healthy oocyte donors under 35 years and healthy recipients under 50 years and were not associated with pregnancy outcomes, emphasizing the power of oocyte quality on the success of intracytoplasmic sperm injection treatment. An oocyte-sharing program that offers good and comparable results is fair and worth being encouraged.