In vitro fertilization (IVF) 'add-ons' are adjunct treatments used in addition to standard IVF protocols, in attempts to improve success rates. However, the benefits for add-ons are often not supported by high-quality evidence. Despite that, many infertile patients are willing to try anything that might help them to improve their chances of having a baby. Therefore, the use of add-ons has been widespread, leading to extensive debate and discussion. The goal for this manuscript was to discuss the ethics underling the use of adjunct therapies in clinical practice before their safety are thoroughly ascertained. IVF patients are routinely offered and charged for a wide range of adjunct treatments that they are told may improve their chance of a live birth, despite there being no clinical evidence supporting its efficacy. Add-on treatments are well accepted by most infertile patients, especially those who have already started their IVF treatments. A particular concern is that many clinics around the world are advertising and offering clinical adjuncts to infertile couples undergoing IVF, however, information on its add-ons is often inaccurate. Information concerning the lack of scientific evidence supporting its efficacy and whether an add-on may cause unanticipated harms or worsens treatment outcomes is not available in most websites. There is a need for transparent information about interventions for IVF patients, a vulnerable population, including uncertainties and risks, to support their decisions regarding the use of certain adjunctive therapies, what may be provided by clear guidelines and effective regulation.