Received March 18, 2022
Accepted October 03, 2022

Objective: Elucidate through a systematic literature review the impact that sperm DNA fragmentation has on embryos from assisted reproduction techniques. Data sources: The studies were analyzed from the “Pubmed” databases; “Base”; and “BVS”. Study selection: The articles selected in the present review included: Cohort and case control studies that addressed the proposed theme and were published between January 1, 2017 and January 31, 2022 in English, Portuguese and Spanish. As inclusion criteria: cohort and case control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor and articles found in duplicate in the databases. Data collect: Number of couples or cycles; Age (Men); Age (Women); Collection type; DNA damage (%); Assisted reproduction activity and techniques. Data Synthesis: In classical in vitro fertilization, a reduction in the fertilization rate, blastocyst rate and embryo quality was observed, in addition to a reduction in the implantation rate and an increase in abortion rates. Intracytoplasmic Sperm Injection: Reduction of blastocyst production rate, embryonic quality, implantation and live birth rate. Artificial insemination: Reduction in pregnancy rate. Conclusion: The fragmentation of sperm DNA proved to be a limiting potential of assisted reproduction techniques.