Received March 29, 2022
Accepted October 03, 2022

Objectives: Acetamiprid (ACP) causes infertility complication and its effect appears to perform by oxidative stress. Melatonin has antioxidative property. Thus, in this experimental study, we examined protective effect of melatonin against toxicopathological changes of ACP on reproductive system parameters of female mice. Methods: The study was conducted in 30 female mice in 5 groups (6 mice in each group) as follow: saline (control group), ACP (10, 20 mg/kg), ACP (10mg/kg) + melatonin (10mg/kg) and ACP (20mg/kg) + melatonin (10mg/kg). All mice were intraperitoneally treated daily for one month. Ovarian histopathological changes, oocytes and in vitro fertilization quality were evaluated between groups. Results: ACP induced histological damages in ovary such as increasing atretic follicles and decrease of oocytes and fertilization quality. These changes were significantly decreased by melatonin. Conclusions: The melatonin can reduce the toxic effects of ACP female reproductive system but need more researches.