Claudia Guilhermino Petersen, João Batista Oliveira, Ana Lucia Mauri, Fabiana C Massaro, Ricardo Baruffi, Anagloria Pontes, Jose Gonçalves Franco Jr
JBRA Assist. Reprod. 2009; 13 (1):25-28
Received October 20, 2008
Accepted November 10, 2008
Abstract
Objective: To investigate the relationship between the presence of meiotic spindle in human oocytes and fertilization rates in ICSI cycles.
Methods: Search strategies included online surveys of databases from 1990 to 2008. Nine trials fulfilled the inclusion criteria
Results: According to the meta-analysis, the results showed statistically significant higher fertilization rate (p<0.0001) when the meiotic spindle was viewed than when it was not. There was heterogeneity in this comparison.
Conclusion: The presence of a birefringent meiotic spindle in human oocytes can predict a higher fertilization rate. This observation has clinical relevance mainly in countries where there is a legal limit on the number of oocytes to be fertilized.
