Juliano Augusto Brum Scheffer, Daniel H Méndez Lozano, René Frydman, Renato Fanchin
JBRA Assist. Reprod. 2007; 11 (2):9-13
Received February 06, 2007
Accepted June 07, 2007
Abstract
During the luteal-follicular transition, FSH is required for survival and further growth of a fraction of ovarian follicles. Basic research data have suggested the relationship between serum AMH levels and antral follicle responsiveness to exogenous FSH.
Objective :To assess the possible relationship between serum AMH levels and antral follicle responsiveness to exogenous FSH.
Design: Prospective Study.
Patients and Methods: We studied 116 IVF-ET candidates undergoing controlled ovarian hyperstimulation (COH) with GnRH agonist and FSH. After the achievement of pituitary suppression and before FSH administration (baseline), serum AMH levels were measured. The number of antral follicles was determined by ultrasound at baseline (small antral follicles; 3-10 mm) and on the day of hCG administration (dhCG; preovulatory follicles; ≥16 mm).
Results: At baseline, median (ranges) serum AMH, E2, and P4 levels were 3.53 (0.71-8.59) ng/mL, 31 (30-50) pg/mL, and 0.25 (0.1-1.6) ng/mL, and median number of early antral follicles were 17±0.25. Serum AMH levels showed a positive correlation with preovulatory follicles on dhCG (r=0.23; P <0.01), and oocytes obtained (r=0.38; P <0.0001).
Conclusion:These data demonstrate a strong association between day 3 serum AMH level and IVF outcome. AMH may offer greater prognostic value than other currently available serum markers of assisted reproductive technology ART outcome.
