Claudia G Petersen, Ana Lucia Mauri, Ricardo L R Baruffi, João Batista Oliveira, Fabiana C Massaro, José Gonçalves Franco Jr.
JBRA Assist. Reprod. 2005; 9 (1):22-26
Received October 10, 2005
Accepted October 12, 2005
Abstract
Introduction: The aim of this prospective and randomized study was to evaluate the efficacy of quarter laser zona thinning assisted hatching (qLZT-AH) in
improving the implantation of embryos in patients with previous implantation failure.
Material and Methods: A total of 150 patients with a history of previous implantation failure were treated with intracytoplasmic sperm injection, and allocated into two groups: group I, only one previous implantation failure, and group II, repeated implantation failures. The patients in each group were randomized at the time of embryo transfer into a control group (no qLZTAH) or experimental group where qLZT-AH was performed. For patients with repeated implantation failures, the implantation rate in those who received laser-thinned embryos was significantly higher (p=0.02) than in those whose embryos were not laser-thinned (10.9 and 2.6% respectively). However, this difference was not observed in patients who presented with only one previous implantation failure. The data demonstrate that qLZT-AH is an effective strategy for improving the implantation of embryos in patients with repeated implantation failures.
