Received April 22, 2023
Accepted May 16, 2023

Introduction: Direct ovum transfer (DOT) has been reinvestigated (after modifications to the methodology) with a view to offering patients who had failed controlled ovarian hyperstimulation (COH) treatment further chances of active management prior to IVF referral. Materiais and Methods: ln all, 19 couples were treated with 40 cycles of DOT. ln order to provide some control data for comparison, results from the IUI programme (during the same time period) were also included. Controlled ovarian hyperstimulation and ovulation was monitored by ultrasound only. The sarne COH regimen was used for both IUI and DOT. Similarly, the same method of semen preparation was used for both. Oocyte recovery was done transvaginally. Patients were sedated using Pethidine and Hypnovel. Two ova and approximately 20000 sperms were then loaded, in 100-150 ui of medium, into a catheter and then placed directly into the uterus via the cervix. ResuIts:From 40 completed DOT cycles seven pregnancies have been established. Amongst IUI patients treated on the same day, six pregnancies were established out of 125 cyces (significant, p<0.04). ConcIusion: The additional modifications of the treatment procedure have further simplified the method. The encouraging results indicate that DOT may be an useful treatment option for COH failures. A larger study is needed.