Received May 11, 2023
Accepted November 11, 2023

Empty follicle syndrome is a rare condition characterized by failure to retrieve oocytes despite repeated careful aspiration of mature precursor follicles during controlled ovarian stimulation cycles. Next, we present a case of empty follicle syndrome in a polycystic ovary syndrome patient, using a gonadotropin-releasing hormone agonist as a trigger for final oocyte maturation. No oocytes were retrieved from the right ovary and the procedure was discontinued. The patient was successfully started on 10,000 unit inj. HCG and 3 oocytes were obtained after 24 hours of retrieval. All oocytes were mature (MII), then fertilization was done by the patient's husband's sperm, and finally 3PN oocytes were formed. The formation of the following 3PN ICSI can be due to oocyte cytoplasmic disorders caused by long-term exposure to gonadotropins and increased number of days of stimulation. Therefore, although the empty syndrome was false in this case and the hCG rescue protocol was able to recover the oocytes, the oocytes were not of good quality, and as previously stated, the empty follicle syndrome cannot be a predictor of subsequent cycles, as in This patient also had the next cycle without any problems.