Received June 01, 2023
Accepted May 03, 2024

Objective: Recent studies show a significant role of neutrophils in reproductive processes. There is an opinion about their participation in the preparation of the cervix for childbirth and the activation of labor, in the postpartum involution of the uterus, in the occurrence of preeclampsia. The objective was to assess the formation of free radicals by neutrophils in the blood of women on the first day after childbirth and to characterize the adrenergic effect on this process. Methods: Venous blood samples were collected and analyzed from 100 female volunteers aged 26-32 years who had 2 or 3 full-term deliveries. Various adrenergic compounds were used for the study (agonists alpha- and beta- adrenoreceptors, adrenoblockers). The intensity of the respiratory burst of neutrophils and the effect of adrenergic substances on them assessed with the power of luminol-dependent latex induced chemiluminescence. Results: showed that activity of neutrophils depends on the stage of the woman's reproductive process: it decreases during pregnancy, reaches the lowest values during childbirth, and increases significantly in the first hours after childbirth. On the first day after childbirth, alpha-1-adrenergic receptors are highly active in neutrophils, through which NADP-H-oxidase is activated and activated oxygen species are formed. At the same time, alpha- or beta-agonists inhibit the radical activity of cells. Conclusion: latex-induced oxidative burst of the woman blood neutrophils correlates with the stage of the reproductive process. Stressful conditions in the postpartum period can suppress the ability of neutrophils to release reactive oxygen species, which increases the risk of postpartum infections.