Received July 07, 2023
Accepted January 15, 2024

The protective potential of Xylopia aethiopica against aluminium-induced ovarian toxicity in Wistar rat was investigated in the study. Twenty five rats were randomized into five groups with five rats per group. Group 1 received only distilled water; Group 2: received 150mg/kg of Aluminium chloride; Group 3: received 150mg/kg Aluminium chloride with 100/kg Xylopia aethiopica seed extracts; Group 4: received 150mg/kg Aluminium chloride with 50 mg/kg Xylopia aethiopica seed extracts, and Group 5: received 150mg/kg Aluminum chloride with 50mg/Kg Zinc Sulphate. For twenty-one days, all administrations were done orally after which the rats were sacrificed following chloroform anesthesia. The ovaries were harvested for histological Examination. The data were analyzed with IBM SPSS software version 21 and the differences in mean values were considered significant at p<0.05. Xylopia aethiopica extracts significantly (p<0.05) protected against the detrimental effects of Aluminum chloride on Luteinizing hormone, Follicle stimulating hormone, Progesterone and Estradiol. The histological analysis of the ovaries showed a significant preservation of the histoarchitecture of the ovary when treated with Xylopia aethiopica extract and zinc sulphate. However, Xylopia aethiopica was more effective in a dose-dependent manner. This study suggests that Xylopia aethiopica has protective potential against Aluminuim-induced toxicity in the ovaries of Adult female Wister Rats.