Received June 20, 2023
Accepted January 27, 2024

Objective: to verify by means of a systematic literature review the effects of the main analgesics on male fertility. Data sources: studies were analyzed using the "Pubmed", "Scielo" and "Lilacs" databases. Study selection: the articles selected for the present review included: cohort studies; cross-sectional studies, clinical trials; complete studies; studies with animal models that addressed the proposed theme and that were published within the stipulated period from March 1, 2013, to March 31, 2023, in English, Portuguese and Spanish languages. These would subsequently have to go through inclusion steps, such as framing the type of study and exclusion criteria. Data collection: author name, year of publication, study population, number of patients, analgesic, time of administration, dose, and effect. Conclusions: in summary, there are in vitro and in vivo studies linking paracetamol and ibuprofen to endocrine and seminal changes detrimental to male fertility. However, more clinical research is needed to determine the doses and timing of administration that affect fertility. The effects of aspirin on male fertility are still unclear due to the lack of consistent studies and methodologies. There is not enough research on dipyrone and its relationship to male fertility, requiring more studies in this area.