Received April 02, 2024
Accepted October 30, 2024

Objective: To compare the efficacy and safety of PPOS and CPOS in high-responder patients undergoing IVF. Materials and Methods: This prospective, RCT included 86 high-responder patients. They were divided into PPOS(n=44) and CPOS(n=42). Both groups underwent COS and various parameters, such as LH surge, cycle cancellation rates, birth rates, implantation rates were measured and compared. Results: The study revealed that LH surge occurred in2.3% of the PPOS group and 2.5% of the CPOS group. The cycle cancellation rates were9.1% for PPOS and 10% for CPOS. Birth rates were57% for PPOS and54% for CPOS. Implantation rates were45% for PPOS and49% for CPOS. There was no significant difference in the duration of stimulation(PPOS: 11.30 � 1.96 days, CPOS: 11.41 � 2.02 days, p-0.807) or the total FSH used(PPOS: 2888.95 � 791.80 IU, CPOS: 2808 � 834.52 IU, p=0.655). The PPOS group had a mean of 19.58 � 8.07 retrieved oocytes, while the CPOS group had a mean of 21.87 � 10.02, showing no significant difference (p=0.807). Similarly, there was no significant difference (p=0.376) in the number of mature(MII) oocytes between the PPOS group(15.67 � 6.23) and the CPOS group (17.08 � 7.96). Post-trigger LH levels were significantly lower in the PPOS group(PPOS: 49.68 � 27.54 IU/L, CPOS: 71.83 � 43.43 IU/L(p-value 0.007), indicating LH surge suppression. Neither group reported cases of ovarian hyperstimulation syndrome(OHSS). Conclusion: PPOS and CPOS offer similar outcomes in high-responder individuals undergoing COS for IVF, except for lower post-trigger LH levels in the PPOS group. Importantly, neither group experienced ovarian hyperstimulation syndrome(OHSS).