Received December 12, 2024
Accepted September 02, 2025

We report the case of a healthy nuligesta, 34 years of age, 70 kg, BMI 23,67 kg2, using ENG 68 mg implant for contraception, in amenorrhea, presenting with 19 antral follicles on initial ultrasound (US), desiring social fertility preservation. Follicular phase controlled ovarian stimulation (COS) was initiated by the application of corifollitropin alfa (CFA) 150 mcg on day 1 and an overlapped dose of CFA 100 mcg on day 5. US monitoring was initiated on the ninth day of stimulation and trigger was performed on day 11, when 6 follicles were ≥ 16 mm, by administration of recombinant chorionic gonadotropin (rhCG) 250 mcg. Follicular aspiration (FA) was performed 36 hours later, resulting in recovery of 13 oocytes, of which 11 metaphase II (MII) were vitrified. Luteal phase COS was initiated one day after the first FA, using CFA 150 mcg. The trigger was proceeded again on day 11, by rhCG 250 mcg, when 8 follicles were ≥ 16 mm, followed by FA 36 hours later, leading to the recovery of 6 MII oocytes, all vitrified. Our report is the first to highlight that a woman attempting fertility preservation who uses ENG implant for contraception may take advantage of it for LH suppression during COS; additionally, it proposes a novel protocol using CFA in overlapped doses, aiming at comfort and lower cost.