Received December 12, 2016
Accepted April 05, 2017

Objective: The study investigated the effect of D-ribose and L-cysteine on aluminium induced testicular damage in male sprague-dawley rats. Method: A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (A-D). Group A (comprised five (5) rats) was designated as the Control that received Physiological Saline while group B, C, and D (comprised ten (10) rats) were administered with 75mg/kg, 150mg/kg and 300mg/kg body weight of aluminum chloride respectively for 39days. At day 40, the aluminum treated groups were subdivided into sub-groups (B1, C1, D1) comprising of five (5) rats each and 30mg/kg body weight of Riboceine were administered for twenty (20) days. Groups B, C and D remained administered on the normal dosage of aluminum chloride for further three weeks (59days). Results: Andrological parameters (Sperm count, motility, morphology and testosterone) in the aluminum treated Group B and C showed no significant difference in their mean values when compare with the control whereas there was a significant reduction in the andrological parameters in Group D rats when compare with the Control. Histo-architecture of the testes “stain with H&E” of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen, leydig cells appear hyperplasia. Group B1, C1 and D1 andrological and histological parameters appeared normal. Conclusion: Riboceine treatment significantly attenuates aluminum-induced testicular toxicity in male Sprague-Dawley in rats.