Received March 03, 2013
Accepted April 13, 2013

Objetive: To evaluate rate blastocyst aneuploidy after Array-CGH in different age groups with different infertility history in couples submitted to IVF. Methods: 598 cycles were evaluated and 2084 blastocysts between 11/2010- 01/2013. Embryo biopsy was performed on blastocyst and sample was performed to Array-CGH analysis. Patients were divided in 4 groups according to maternal age: A)≤34years old(yo); B)35-37yo; C)38-40yo and D)≥41yo. The couples infertility history were classified in 6 groups: 1)+1 IVF failure (IVFF) and +1 abortion (AB); 2)1 IVFF without PM; 3)1AB without IVFF; 4)+2 IVF without PM; 5)+2 AB without IVFF and 6) no failures. The aneuploidies were divided in 4 groups: I) Monosomy; II)Trisomy; III)Multiple and IV)Complex. Were also verified the rate of deletions, duplications and DNA degradation. Results: Analysis of aneuploidy rate by age groups showed statistical differences in group 1 [AXD (p = 0.041) and BxC (p = 0.005)], Group 3 [AxB (p = 0.05), AxC (p=0.05) and AXD (p=0.02)], Group 4 [AXD (p=0.011), BxD (p=0.002) and CXD (p=0.03)], Group 5 [AxC (p=0.013), AXD (p=0.001) and CXD (p=0.018)] and Group 6 [AxC (p=0.001), AXD (p=0.001), BxC (p = 0.013) and BxD (p = 0.001)]. Group 2 did not differ between age groups. However, the comparative analysis between the types of aneuploidy found in all age groups and infertility factors showed no statistically significant differences Conclusions: Our study suggests that the presence of embryonic chromosomal abnormalities is not related with the infertility history. Similar maternal age groups with different backgrounds showed the same incidence of the chromosomal abnormalities.