Received December 16, 2016
Accepted May 10, 2017

Objective: To compare the results obtained with two different GnRH agonist dosage: 0,3mg versus 0,4mg to trigger ovulation in oocyte donor cycles. Methods: Experimental controlled randomized trial including 40 patients of a private practice center. Patients were randomized in two groups. Group A received an only dose of Triptorelin 0,3mg (Decapeptyl) 36 hours before pick-up. Group B patients received Triptorelin 0,4mg (Decapeptyl) before pick-up to final oocyte maturation. We evaluate the total number of oocytes collected, the number of mature oocytes and total days of ovarian stimulation. Results: The average of total collected oocytes were 16 (Group A) versus 15 (Group B) and the mean of mature oocytes were 13 versus 12 respectively. The single variable showing a difference was the percentage of mature oocytes which was greater in the Group A resulting in 84.6% in contrast with those treated with 0.4 mg of Triptoerlin (78,6%), although this differences were not statistical significant (p=0,35). Days of stimulation did not differ between groups. No cases of empty follicle syndrome were reported. Conclusions: We found that an increase from 0.3 to 0.4 mg of triptorelin in an oocyte donation program might not improve the results. Nevertheless, more studies might be necessary, not only in oocyte donors but in sterile women in order to evaluate how GnRH agonist dosage could affect the results among other factors.