Received February 13, 2017
Accepted August 07, 2017

Objective: The aim of this study was to compare the endometrial expression of milk fat globule-EGF factor 8 (MFG-E8), its receptor integrin αvβ3, and leukemia inhibitory factor (LIF) in patients with endometriosis and infertility and in healthy fertile patients during the window of implantation. Methods: Five patients with peritoneal endometriosis and infertility (study group) and four healthy fertile patients (control group) were recruited. All patients had their endometriosis diagnosis made or excluded by laparoscopic surgery; the study group was subjected to the surgery for infertility investigation and the control group for tubal ligation. Endometrial biopsies were performed in all patients during the window of implantation (LH+8 to LH+10), and then the samples were analyzed by immunochemistry for MFG-E8, integrin αvβ3 and LIF. Results: In patients with endometriosis and infertility, expression of MFG-E8 was significantly increased in the glandular epithelium when compared to healthy fertile patients (P<0.001). Moreover, LIF expression was lower in patients with endometriosis and infertility (P<0.05). Nevertheless, we found no difference in integrin αvβ3 expression between the groups (P=0.084). Conclusions: This study showed for the first time that MFG-E8 expression is impaired in the endometrium of patients with endometriosis and infertility during the window of implantation. Moreover, LIF is also diminished in these patients endometrium as shown before.