Antonella Sampo, Palena Celina, Luciano Ganzer, Virginia Maccari, Gustavo Estofán, Mariana Hernández
JBRA Assist. Reprod. 2017; 21 (3):212-216
Received February 05, 2017
Accepted June 17, 2017
Abstract
Objective: To assess the effect of Body Mass Index (BMI) on the results obtained in ICSI cycles.
Methods: We studied 266 ICSI cycles realized between January 2014 and December 2016. Patients were grouped according to their BMI in: Normal (18.5-24.9), Overweight (25.0- 29.9) and Obese (>30).
We compared between the groups: antral follicles number, ovarian stimulation lenght, gonadotropin dose used, maximum oestradiol value, follicles developed /antral follicles, retrieved oocytes/developed follicles and mature/retrieved oocytes, normal fertilization rate, embryo achieved/ normal fertilized oocytes, clinical pregnancy and implantation rate. Kruskal-Wallis and Chi square test were used. p < 0.05 was considered significant.
Results: Normal, Overweight and Obese patients presented comparables values for antral follicles number (11.6±5.4, 12.5±5.5, 12.2±5.7), ovarian stimulation length (7.5±1.4, 7.6±1.1, 7.8±1.3) and gonadotropin dose used (2043±489, 1940±536, 2109±605).
Obese patients had lower values of oestradiol (1560±610, 1511±635, 1190±466; p=0.018), developed follicles (81%, 76%, 70%; p<0.0001); and retrieved oocytes (91%, 90%, 84%; p=0.0017); and not significantly lower values of mature oocytes (82%, 82%,y 77%; p=0.26).
Groups had comparable fertilization rate (72%, 73%, 69%) and embryo achieved rate (67%, 63%, 72%). Normal group showed higher but not significant pregnancy and implantation rates (43%, 40%, 38%, p=0.53; and 33%, 26%, 23%; p=0.11), and significantly higher ongoing pregnancy rate (37%, 33%, 33%, p=0.042)
Conclusion: Increased BMI patient had impaired ovarian response and pregnancy rate in ICSI cycles.