Maria Cecilia Cardoso, Alessandra Evangelista, Cássio Sartório, George Vaz, Caio Luis Vieira Werneck, Fernando Marques Guimarães, Paulo Gallo de Sá, Maria Cecília Erthal
JBRA Assist. Reprod. 2017; 21 (3):217-221
Received February 05, 2017
Accepted June 17, 2017
Abstract
Objetive: Evaluate the efficacy of the double-stimulation protocol over conventional ovarian stimulation in order to recover a more adequate number of oocytes to increase the number of embryos to be transferred or to be genetically analyzed.
Methods: A retrospective and comparative study with 13 patients who underwent unsuccessful IVF cycles with a conventional antagonist ovarian stimulation protocol and repeated the attempt with a double stimulation protocol. The following variables were analyzed: number of oocytes collected, mature oocytes collected, fertilization rate, blastocyst rate, biopsied blastocyst rate and euploidy rate.
Results: The double stimulation protocol had a significant higher number of oocytes collected (p=0.007) and mature oocytes to be injected (p = 0.01). There was no statistical difference in fertilization (p=0.78) and blastocyst (p=0.59) rates.
Conclusion: Double stimulation favors patients who are at risk of incurring several attempts of IVF in order to achieve pregnancy
