Ivan Henrique Yoshida, Monise Santos, Caroline Zulim Berton, Caroline Lopes Chiarella, Michelli Suemi Tanada, Emerson Barchi Cordts, Waldemar Pereira de Carvalho, Caio Parente Barbosa
JBRA Assist. Reprod. 2018; 22 (2):113-115
Received July 18, 2017
Accepted January 09, 2018
Abstract
Objective: The transfer of euploid embryos allows better implantation rates. In Brazil, evaluation of morphology is performed to select the best embryo, since genetic analysis is still a high-cost implement. The study aimed to evaluate if there is a correlation between morphology of trophectoderm and its chromosomal status.
Methods: 113 blastocysts formed in D5 / D6 from 58 cycles of in vitro fertilization from January 2016 to May 2017 were evaluated. All patients with indication for PGD / PGS were included in this study. The mean age of women was 37.04 (± 5.65). Biopsied blastocysts were classified according to their morphology. Cells were sent for genetic analysis using the CGH array, SNP array or NGS techniques. Statistical analysis was performed using the chi-square test, considering P≤0.05.
Results: 44 (38.9%) blastocysts were euploid after chromosome analysis. The blastocysts with trophectoderm grade A presented 71.43% of euploidy, those with grade B, 60% and those with grade C, 19.67% (P≤0.05).
Conclusion: Although the best trophectoderm morphology scores show the highest euploidy rates, only this evaluation is not enough to guarantee the genetic viability of the embryo.
