Received November 16, 2013
Accepted November 16, 2013

OBJECTIVES: To compare the incidence of pathologies in patients with 3-5 and with 2 previous recurrent abortions and to analyze the risk of further abortions. METHODS: 189 of 260 patients with 2 (n=80) and 3-5 (n=109) recurrent abortions were successfully contacted (72,6%) to report on the outcome of their following pregnancy after profound abortion related diagnostics. All patients were diagnosed by hysteroscopy, chromosomal analysis of both the patient and her partner, endocrine analysis including increased concentrations of testosterone, DHEA-S, prolactin, basal LH and TSH, autoimmune analysis including anti-phospholipid antibodies, anti-cardiolipin, anti-thyroid globulin, anti-thyroid peroxidase, anti-nuclear antibodies and analysis of coagulation disorders such as Factor V Leiden-, Factor II- and MTHFR-mutation, APC-resistance, decreased protein S-, protein C-, ATIII-, and factor XII-concentrations and increased factor VIII- concentrations. Patients had received surgical intervention (16,8%), genetic counseling (3,5%), treatments with thyroid hormones (18,9%), bromocriptine (4,2%), aspirin (49,7%), heparin (43,4%) or folic acid 5mg (42%) during the following pregnancy (n=143). RESULTS: The incidence of hemostaseological and MTHFR-mutations was 3.3 respectively 2.4 times higher (p=0,0004 respectively p=0,0092) in the group with previous 3-5 abortions. The risk of further abortions was 32.9% after 3-5 abortions in comparison with 13.1% after 2 abortions (p=0,0064). CONCLUSION:Hemostaseological and MTHFR-associated pathologies seem to play a major role in recurrent abortions. In spite of the treatment of these pathologies, the risk of further abortions remains significantly higher following 3-5 previous abortions in comparison to 2 abortions.