Received February 22, 2018
Accepted August 31, 2018

Objectives: This study aimed to investigate ‘Cytoprotective effect of Lawsonia inermis aqueous leaf-extract on aluminium-induced Oxidative stress in Histomorphometric of the Seminiferous tubule and Stereology of Germ Cells of adult male Wistar rats’ with the objectives on its effect on Histomorphometric of the Seminiferous tubule and Stereology of Germ Cells. Methods: Thirty five adult male Wistar rats, weighing between 100-196g and fifteen mice of the same weight range were used. Lawsonia inermis extracts and aluminum chloride (AlCl3) were administered for a period of three (3) weeks with Five (5) rats per group. Group 1 (control): Given rat pellets and distilled water. Group 2: Given 60mg/kg/d aqueous extract. Group 3: Given 0.5mg/kg/d of AlCl3. Group 4: Given 0.5mg/kg/d of AlCl3 and 60mg/kg/d of aqueous extract orally. Group 5: Given 0.5mg/kg/d of AlCl3 and 75mg/kg/d of aqueous extraxct orally. Group 6: Given 0.5mg/kg/d of AlCl3 and 100mg/kg/d of aqueous extract orally. Group 7: Given 0.5mg/k/d of AlCl3 and 5mg/Kg/d Ascorbic acid orally. Twenty four hours after the last administration, the animals were weighed, sedated with chloroform and blood was collected. The testes were removed and weighed. Results: There were statistically significant changes in the percentage seminiferous tubular, seminiferous ductal diameter within the experimental animals in all the groups (p<0.05). Stereological finding revealed increase in spermatogonia, primary spermatocytes, round Spermatids and elongated spematids, spermatozoa, sertoli cells population of the control rats while the rats given 0.5mg of aluminum chloride per kg of body weight have the least value (p<0.05). Conclusion: In this current study full knowledge has been demonstrated as it affected the histomorphometry of the seminiferous tubule and stereology of germ cells in testes where stress impacts were most felt and subsequently translated into drastic reproductive dysfunction and distortion of spermatogenesis.