Received November 16, 2013
Accepted November 16, 2013

OBJECTIVE: To demonstrate the utility of ovulation induction using clomiphene Citrate and gonadotrophin, associating this with oocyte vitrification for low respon- der patients with egg donation prescription. METHODS: Low responder patients with egg donation prescription were included in this study. We propose them to make three ovarian stimulation cycles with Clomiphene citra- te and gonadotrophin followed by oocyte vitrification. Later on oocytes were warmed and inseminated by ICSI. We prepare the endometrium with an LHRH analogue, Estradiol and progesterone. Low responder patients who followed a short stimulation protocol were included as a control group (n = 35). RESULTS: Twelve patients completed the protocol. The mean age (38.2 vs 35 years) and AMH levels (0.98 vs 0.94 ng / ml) were similar in both groups. The average total oocytes per patient was 4.3 (2.7) and 2.84 per cycle (1-4) being 1.85 (1-3) in the control group. Oocyte survival and fertilization rates were 80% and 78%. The average number of embryos transferred, implantation rate and ongoing pregnancy rate per ICSI were: 2.8 vs. 1.7, 22% vs 26% and 33% vs 28%. CONCLUSION: Clomiphene is an effective ovulation inductor and its endometrial deleterious effect can be avoided with oocyte vitrification. Even though differences were not statistically significant, the study group included patients of worse prognosis (cancelled cycles, no oocyte retrieved, repeated failures) when compared with the control group. Using this strategy we achieved three healthy children birth and a normal ongoing pregnancy of 28 weeks in women otherwise requiring egg donation.