Received November 16, 2013
Accepted November 16, 2013

OBJECTIVE: Retrospective analysis of the results of an oocyte donation program where the final oocyte maturation in the donor was triggered in previous cycles with human chorionic gonadotropin (hCG) and in subsequent cycles with gonadotropin-releasing hormone agonist (GnRHa). METHODS: We evaluated retrospectively 20 oocyte donors in 70 oocyte retrievals between 2009-2011 (n = 48, hCG; n = 22, GnRHa). The total number of recipients was 130. One hundred and twelve cycles were transferred at the blastocyst stage (n = 70, hCG; n =42, GnRHa). The fertilization, blastocyst formation, pregnancy, implantation, miscarriage, birth and multiple birth rates were compared. In addition, we studied the ovarian hyperstimulation syndrome (OHSS) rate. RESULTS: The fertilization, blastocyst formation, pregnancy, implantation, miscarriage, birth and multiple birth rates were not significantly different between groups. However, significant differences (p <0.02) in the OHSS rate were observed. Cases of OHSS were not detected in the GnRHa group in 22 oocyte retrievals, whereas in the hCG group there were 10 OHSS in 48 oocyte retrievals. CONCLUSIONS: The results observed in oocyte donation cycles triggered with hCG or GnRHa were similar. Therefore, the final oocyte maturation can be triggered with GnRHa instead of hCG in oocyte donors with risk of OHSS development, without compromise embryo development and clinical outcome in the oocyte recipients patients.