Cecilia de Souza Monteiro, Bruno Brum Scheffer, Rafaela Friche de Carvalho, Juliano Brum Scheffer
JBRA Assist. Reprod. 2019; 23 (4):414-417
Received August 27, 2018
Accepted May 01, 2019
Abstract
One in six couples worldwide will experience at least one infertility problem during their reproductive years. Between 5.6% and 35.1% of women will exhibit poor ovarian response. A variety of methods have been applied to improve ovarian response, including dehydroepiandrosterone. In the ovaries, dehydroepiandrosterone promotes follicular development and granulosa cell proliferation by increasing intraovarian androgen concentrations while simultaneously enhancing the level of follicular insulin-like growth factor-1, which promotes folliculogenesis. Dehydroepiandrosterone supplementation may improve in vitro fertilization outcomes and ovarian response in patients with poor ovarian response. However, a few questions still loom over the effectiveness of dehydroepiandrosterone.
