Received November 17, 2013
Accepted November 17, 2013

OBJECTIVE: To analyze retrospectively the results of our oocyte donation program. In a paired analysis; donors were treated with human chorionic gonadotropin (hCG) and in a subsequent cycles with gonadotropin-releasing hormone agonist (GnRHa). METhODS: We evaluated retrospectively 20 oocyte donors in 70 oocyte retrievals between 2009- 2011 (n = 48, hCG; n = 22, GnRHa). The total number of recipients was 130. One hundred and twelve cycles were transferred at the blastocyst stage (n = 70, hCG; n =42, GnRHa). The fertilization, blastocyst formation, pregnancy, implantation, miscarriage, birth and multiple birth rates were compared. In addition, we studied the ovarian hyperstimulation syndrome (OHSS) rate. RESULTS: The fertilization, blastocyst formation, pregnancy, implantation, miscarriage, birth and multiple birth rates were not significantly different among the groups. In the GnRHa group, the frequency of OHSS was 0% while in the group with hCG trigger, OHSS frequency was 20.8% (10/48), this was statistically different (p<0.02). CONCLUSIONS: The results observed in oocyte donation cycles triggered with hCG or GnRHa were similar. Therefore, the final oocyte maturation can be triggered with GnRHa instead of hCG in oocyte donors with risk of OHSS development, without compromise embryo development and clinical outcome in the oocyte recipients patients.