Received May 22, 2019
Accepted December 01, 2019

Preimplantation Factor (PIF) is a novel fifteen amino acid linear peptide (MVRIKPGSANKPSDD) in which has different biological functions in mammalian species e.g. its role in neuron restoration, pregnancy, its related disorders and also in the autoimmune disease. Since all clinical studies have shown that PIF has both local and systemic effects, it can be considered as an integrated therapy for the treatment of inflammation conditions, along with the prevention of advanced disease. The synthetic PIF (sPIF) analog was found to be a good representative with native PIF action, regulates peripheral immune cells to achieve endurance without immune suppression as an effective agent in nonpregnant autoimmune models. This document provided useful information from evidence-based studies so far about the different functional aspects of the PIF.