Cecilia de Souza Monteiro, Erica Becker de Sousa Xavier, Ricardo Mello Marinho, João Pedro Junqueira Caetano
JBRA Assist. Reprod. 2020; 24 (3):324-331
Received May 14, 2019
Accepted November 15, 2019
Abstract
Primary ovarian insufficiency is a cause of infertility that affects about 1% of women under 40 years old, and is considered as idiopathic in 75% of cases. This review aims to carry out a critical synthesis of the knowledge of the chemical agents likely to affect follicular stock in humans and / or animals, by direct toxicity to follicles, or by increasing their recruitments. For the majority of toxic agents, only experimental data are currently available. We propose a strategy to encourage progress in identifying occupational factors responsible for premature ovarian failure.
