Mohammad Amin Behmanesh, Seyedeh Mahsa Poormoosavi, Yousef Pareidar, Behnam Ghorbanzadeh, Ahmad Mahmoodi-kouhi, Hossein Najafzadehvarzi
JBRA Assist. Reprod. 2021; 25 (1):28-33
Received October 26, 2019
Accepted April 30, 2020
Abstract
Objective: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM including use of medicinal herbs. The present study aimed to evaluate the role of Pistacia atlantica extract in the protection of ovary damage streptozotocin (STZ)-induced DM in rats.
Methods: This experimental study was performed on 40 adult female Wistar rats. The animals were divided into five groups of control (A), DM (STZ by 60 mg/kg- intraperitoneally) (B), DM + hexane extract of P. atlantica (200 mg/kg -orally) (C), P. atlantica extract (D) and DM + glibenclamide (200 mg/kg -orally) (F). The experiment continued for four weeks, and oral administrations were performed daily. After euthanasia, rats' ovaries were removed. Parameters such as blood glucose and levels of oxidative stress markers as well as histological ovary structure were evaluated.
Results: Blood glucose and malondialdehyde (MDA) level and the number of atretic follicles was elevated and catalase (CAT) and superoxide dismutase (SOD) levels and the number of corpora lutea was decreased significantly in untreated diabetic rats. These changes were returned to normal or diminished with P. atlantica extract and glibenclamide in treated rats.
Conclusions: The extract of P. atlantica has antihyperglycemic and antioxidative properties and it decreases ovarian complications in experimental diabetes mellitus.
