Received January 02, 2020
Accepted June 20, 2020

Objective: One of the remarkable causes of infertility in men is oxidative stress having a reducing effect on their reproductive function. In the present study, the efficacy of supplementation with antioxidants and L-Carnitine (contained in Androferti) on the semen parameters has been investigated. Methods: A total number of 180 infertile male patients diagnosed with idiopathic oligoasthenoteratospermia (OAT) included in this study. The semen sample of 59 patients were analyzed before and after an oral antioxidant treatment with the commercial name of Androferti (containing 1500 mg of L-Carnitine, 60 mg of vitamin C, 20 mg of coenzyme Q10, 10 mg of vitamin E, 10 mg of zinc, 200 µg of vitamin B9, 50 µg of selenium, 1 µg of vitamin B12). All of the patients received Androferti twice a day for 3 months. Results: Significant improvement was observed in the sperm concentration (P = 0.004) after antioxidant supplementation. Also, the sperm morphology of semen samples meaningfully improved (P = 0.01) after treatment. However, the sperm motility did not change statistically significant after antioxidant treatment (P = 0.2). Conclusions: Antioxidants supplementation containing 1500 mg L-carnitine can improve the semen quality in infertile men diagnosed with idiopathic OAT. However, further studies are required to determine the antioxidant effects on reproduction function.