Received February 04, 2020
Accepted August 20, 2020

Background: Literatures has shown that synthetic antipsychotic drugs induce reproductive toxicity, while psychiatric patients treated with traditionally used antipsychotic herbs (Rauwolfia vomitoria) showed no traces of reproductive toxicity. Thus, this study aimed to investigate the expression of CREM, PRM I and II genes in the testes of Wistar rats treated with antipsychotic drugs: chlorpromazine, Rauwolfia vomitoria (RV) and co-administration of reserpine, zinc and ascorbate (RAZ). Methodology: Seventy-two adult male Wistar rats with average weight of 180+4.67g were divided into nine groups (A-I) (n=5). Group A was administered saline (control) while rats in Groups B and C received 10 and 20 mg/kg body weight (bwt) of chlorpromazine respectively. Groups D and E received 2.5 and 5 mg/kg bwt of reserpine respectively while Groups F and G received 150 and 300 mg/kg bwt of RV leaf extract. Groups H and I received (2.5+5+100) mg/kg bwt and (5+10+200) mg/kg of combination of RAZ respectively for 56 days.. Result: CREM, PRM I and II genes were significantly downregulated while significant decreased in serum FSH and testosterone concentration were observed in Chlorpromazine and Reserpine treated groups. Groups H and I showed high significant upregulation of CREM, PRM I and II genes and high significant increased in serum FSH and testosterone concentration. Conclusion: The study concluded that HPT-Axis was impaired by chlorpromazine and reserpine while RV and combination of RAZ administration enhanced the axis in animal model. The study recommended that synthetic antipsychotic drugs should be taken with Zinc and Ascorbate in order to improve reproductive toxicity associated with antipsychotic drugs. Further study on human is needed to confirm these.