ISSN 1518 0557
Ongoing pregnancy and healthy live births following very short ovarian stimulation of incidentally observed big antral follicles in oligoamenorrheic patients with extremely decreased ovarian reserve

2021; 25
Volkan Turan, Meltem Sonmezer, Murat Sonmezer
JBRA Assist. Reprod. 2021; 25 (2):324-327

Received April 30, 2020
Accepted November 01, 2020
Abstract

In the present case series our aim is present seven patients with extremely decreased ovarian reserve and oligoamenorrhea conceived with in vitro fertilization following a very short ovarian stimulation of incidentally detected big antral follicles.Women persuing in vitro fertilization due to premature ovarian failure risk were involved. When an incidental growing antral follicle was detected under ultrasound, immediate ovarian stimulation was initiated if the blood estradiol, luteinizing hormone and progesterone levels were correlated. Serum anti-mullerian hormone measurements of all patients were consistent with extremely diminished ovarian reserve (ranged between 0.01 and 0.09 ng/ml) and FSH levels varied between 13-104 IU/l. Mean stimulation length ranged between 2-4 days. A total of 8 oocytes were retrieved; 6 MII, 1 GV and 1 degenerated. All 6 MII oocytes were fertilized with intracytoplasmic sperm injection. Two patients conceived after fresh embryo transfer, whereas the one conceived following frozen thawed embryo transfer. Ongoing pregnancy rate was 50% per transfer, and 2 of them resulted in a healthy live birth. In conclusion, close monitoring of oligoamenorrheic infertile patients using ultrasound and blood hormone levels who are at high risk of imminent ovarian failure is very important. Albeit low, the possibility of having a healthy pregnancy following “a very short ovarian stimulation” in such a specific patient group is emphasized.


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doi: 10.5935/1518-0557.20200095

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