Received May 03, 2020
Accepted October 05, 2020

Objective: Follicular Output Rate (FORT) is an efficient quantitative and qualitative marker of ovarian responsiveness to gonadotropins .Transdermal testosterone (TT) has been used as adjuvant therapy to gonadotrophins in order to improve the ovarian response in poor responders (PR). The aim of this study was to analyze if the use of TT can improve folicular sensitivity to gonadotropins using FORT. Methods: This retrospective study, held in a tertiary-care university hospital and 90 patients PR included, according to the Bologna criteria Patients in Group 1 (n=46), transdermal application of testosterone preceding gonadotrophin ovarian stimulation under pituitary suppression. In Group 2 (n=44) ovarian stimulation was carried out with high-dose gonadotrophin in association with minidose GnRH agonist protocol. We analyzed ovarian stimulation parameters and IVF autcomes. Antral follicle count(AFC) (3-8 mm) before ovarian stimulation and Pre-ovulatory follicle count (PFC) (16-22 mm); day of hCG administration were determinated. The FORT was calculated by the ratio PFCx100/AFC. Results: Baseline characteristics and ovarian reserve parameters were similiar in both groups. FORT and oocytes retrieved were significantly higher in the group 1 vs group 2. There were no significant differences in pregnancy rates. In group 1 there was a significantly correlation between FORT and AFC. Conclusion: This study suggests that the potential beneficial mechanism of TT in poor responder patients may be based on increasing of the antral follicle sensitivity to the action of gonadotrophin treatment. FORT is an excellent tool to demostrate this regard