Received April 17, 2020
Accepted October 22, 2020

Objective: The present study aimed to evaluate reproductive outcomes and determine the predictors of clinical pregnancy and live birth in women with elevated basal follicle-stimulating hormone (FSH) levels, who have undergone intracytoplasmic sperm injection (ICSI) treatment. Methods: This retrospective study included 1011 ICSI cycles of women with high basal FSH levels (>10 IU/L) from a tertiary university IVF center between 2010 and 2015. Logistic regression analysis was performed to evaluate the prognostic factors of clinical pregnancy and live birth. Results: Among the 1011 ICSI cycles, the clinical pregnancy and live birth rates per oocyte retrieval were 19.5% and 14.3%, respectively. The live birth rates were 21.1% and 1.7% in women aged ≤30 years and those aged ≥40 years, respectively. In addition, the live birth rate was 1.47-fold higher in women from whom >3 oocytes were retrieved than in those from whom ≤3 oocytes were retrieved (p = 0.047). Logistic regression analysis indicated that categories of age (≤30, 36-39 and ≥40), level of basal FSH (≥20 IU/L) and the ovarian response (≤3 or >3 oocytes retrieved) were significantly associated with live birth. Conclusions: Our study indicated that the age, the level of basal FSH, and the ovarian response are independent predictive factors for clinical pregnancy and live birth among women with basal FSH levels >10 IU/L.