Table 3. Development of zygotes to blastocysts and blastocyst quality depending on embryo morphology assessed at day three.
Embryo morphology Grade 1 and 2a Grade 2b Grade 3 Grade 4
Number of embryos 1349 712 117 594
Blastocyst formation rate 48.0% (a) 20.5% (b) 17.1% (c) 3.2% (d)  
Number of blastocysts 648 146 20 19
Proportion of good quality blastocysts 16.2% (e) 13% (f) 10% (g) 10.5% (h)

a versus b p<0.0001; 95% CI 23.5 to 31.5
b versus c NS
c versus d p<0.00001; 95% CI 6.9 to 20.9
e versus f, g and h NS
Χ2 test